A new frost could heal stubborn diabetic injuries in less than 2 weeks

For people with diabetes, high blood sugar can damage blood vessels and nerves, causing chronic injuries that remain open for months. But a new frost -based treatment could massively accelerate the healing process of people with diabetes, allowing injuries to close in a few days, according to a new study.

The new treatment targets thrombospondin-1 (TSP-1), a protein that inhibits the growth of new blood vessels, a crucial step in the healing process. The targeting of this protein has increased the formation of new blood vessels in human endothelial cells and in diabetic mouse models, leading to a remarkable closure rate in less than two weeks. A team of researchers from various institutes in China has unveiled the new technology in a study published in the journal Burns and trauma.

“Our results demonstrate the power to combine advanced tissue engineering with molecular biology. By targeting TSP-1 with MIR-221OE-Sevs encapsulated in GELMA, we have not only improved the function of endothelial cells, but also ensured a sustained and localized therapeutic effect,” Chinese Chinese Bat, in a press release.

Diabetic wounds have an increase in TSP-1 levels in endothelial cells, cells border blood vessels, according to previous studies. TSP-1 obstructs their ability to divide and go where they have to go. Study researchers have developed a way to reduce TSP-1 levels.

The technology uses small extracellular vesicles (SEV)-Bags based on the membrane generally released by cells-loaded with MIR-221-3P, a microarn which disrupts the production of TSP-1 in endothelial cells.

The researchers encapsulated these SEVs in a hydrogel, which imitates the extracellular environment and provides a controlled and controlled release of MIR-221-3P on the site of the wound. In diabetic mouse models, the frost has considerably accelerated healing, leading to a rate of wound closure of 90% within 12 days, achieving only 20% in untreated mice during the same period.

The next steps are to bring the new frost in clinical trials, according to the authors. “This breakthrough could revolutionize how we approach diabetic wounds, with the potential to considerably improve the quality of life of patients,” Shen said in a statement.